DAO enzyme
The main enzyme responsible for breaking down histamine in the body. Its deficiency is related to HIT.
Diamine oxidase (DAO) is a key enzyme found primarily in the intestinal mucosa and liver. Its main function is to break down histamine taken from food or produced in the body. Insufficient activity or amount of DAO enzyme leads to the accumulation of histamine, which manifests itself in the symptoms of histamine intolerance.
Related terms
The second major enzyme responsible for breaking down histamine. Unlike DAO, it works inside cells within the brain, lungs, skin, and liver. It cannot be supplemented in capsule form.
DAO enzyme supplementation for better breakdown of dietary histamine in people with HIT.
Substances that reduce the activity of the DAO enzyme, which worsens the breakdown of histamine.
Substances that the DAO enzyme needs to do its job, mainly copper and vitamin B6. Without them, the enzyme cannot work at full capacity, even if there is enough of it in the body.
An enzyme that breaks down biogenic amines, such as tyramine or serotonin. It also completes the degradation of histamine after it has been processed by HNMT.