Cumulative effect
A build-up of histamine in the body from various sources that exceeds tolerance and triggers symptoms.
The cumulative effect describes a situation where histamine from various sources (food, own production, impaired degradation) gradually accumulates in the body. If the total amount of histamine exceeds the individual tolerance limit, the symptoms of histamine intolerance will appear. It is the sum of all factors that increase the level of histamine or decrease its breakdown.
Related terms
Substances that release histamine from cells, worsening the symptoms of HIT.
The amount of histamine the body can still break down without issues. It is not fixed and changes from day to day depending on health, medications, hormones, and stress.
Immune system cells that release histamine and other mediators in response to HIT triggers.
Medications that prevent histamine from binding to receptors. However, they do not break histamine down; they only blunt its effect. In this way, they differ from DAO supplementation.
The process by which microorganisms convert substances. It is key in HIT because it increases the histamine content of food.